Introduction: Irritable Bowel Syndrome (IBS) is a prevalent disorder that seems to raise as the consequence of psychological disorders and complications in central nervous system. There are different psychological problems accompanying IBS as 80-90% of the IBS patients are suffering from mental-psychological disorders. Psychological issues including anxiety and depression have been reported in patients diagnosed with IBS. Methods: The aim of the current study was to review the pathophysiology of IBS with the emphasis on the central nervous system through investigating on various relevant studies using verified database such as PubMed, MEDLINE and Google Scholar. Findings: The review of different research studies related to the brain structure and functioning of IBS patients revealed that factors like stress, childhood experiences as well as living in stressful environments promotes manifestation of the syndrome. moreover, the was significant findings found on the manifestation of depression symptoms aside with physical signs associated with IBS. Besides, emotional and cognitive factors in IBS afflicted people differs from healthy individuals. Conclusion: Being one of the most prevalent functional disorder, IBS has a vast and profound association with psychological factors. Different studies shows that stress, depression as well as physical symptoms are more prevalent in IBS patients; hence taking more consideration on psychotherapy and psychological issues apart from non-pharmacological treatments in these patients along with pharmacological treatment alleviates the IBS symptoms and decreases the treatment costs in this prevalent syndrome.
roshani T, fazilat A, roshani F. Investigating the Association of brain and psychological disorders with Irritable Bowel Syndrome (IBS):. NPWJM 2022; 10 (37) : 6 URL: http://npwjm.ajaums.ac.ir/article-1-950-en.html