Aim: Cardiovascular disease is one of the most common causes of mortality in advanced countries today. Fibrinogen and resistin are two important markers of inflammation that predict atherosclerosis. The aim of this study was to investigate the effect of eight-week aerobic training and two weeks of detraining on the levels of resistin and fibrinogen in elderly men. 
Methods: 22 inactive elderly men were selected from nursing homes and randomly divided into experimental and control groups of 11. The experimental group performed an aerobic exercise with 55% to 70% of maximum heart rate for 8 weeks, 3 sessions per week and 30-45 minutes in each session. Then they stopped their training for two weeks. In the entire study period, the control group performed their daily activities only. Blood samples were taken before, after the eighth and tenth weeks. The Kolmogorov-Smirnov test, repeated ANOVA and Bonferron's post hoc test were used to analyze of the data (p≤0.05). 
Results: There was no significant difference in the level of resistin (p = 0.40) and fibrinogen (p = 0.95) changes in the control group in the first, eighth and tenth weeks. However, the levels of resistin (p = 0.01) and fibrinogen (p = 0.001) in the experimental group were significantly lower in the 8th weeks than in the control group. Fibrinogen levels in the 10th weeks were significantly higher than the eighth weeks (p = 0.001). 
Conclusion: It appears that eight weeks of aerobic training led to a significant reduction in the resistin and fibrinogen in older men. However, after two weeks of detraining, the levels of reduced fibrinogen increased again.