Introduction: Hypertension is a major non-communicable disease that is the reason of above 6 percent of human death around the world and if untreated can be complicated by myocardial ischemia and infarction, osteoporosis, renal failure, stroke and death is.

Material and Methods:  In this survey the effect of intraperitoneal injection of 50mg/kg hyoscyamuzides and 100mg/kg metanolic extracted from hyoscyamous niger on high blood pressure after injection of 0.013 mg/kg epinephrine during 28 days in three groups of eight male Wistar rats was studied and mean systolic, diastolic, arterial and pulse pressure via the lower tail vein were recorded by Physiograph.

Results: Methanol and hyoscyamuzides extracted from hyoscyamous niger decreased systolic, diastolic, mean arterial and pulse pressure Significantly (p<0/05) and lowering effect on mean arterial pressure was more relevant (p<0/01).

Conclusion:  Methanol and hyoscyamuzides extracted from hyoscyamous niger are more effective in mean arterial pressure probabely due to beta-blockers activity of these drugs.