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Dengue fever: epidemiology, clinical manifestations, diagnosis, and therapeutic strategies
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Mahdi Amirzadeh   , Mousa Ahmadi , Shahed Ahmadi |
| Shahid Beheshti University of Medical Science |
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Abstract: (71 Views) |
Background: Dengue is a mosquito-borne viral disease transmitted by Aedes mosquitoes, which has rapidly spread in recent years, putting half of the world’s population at risk. Various factors, including urbanization and climate change, have contributed to its increasing transmission. Clinical symptoms range from mild fever to severe cases such as dengue shock syndrome. Currently, no specific antiviral treatment is available, and the primary control strategies include vector control and vaccination.
Methods: This study follows a systematic review methodology based on PRISMA guidelines. Articles were retrieved from PubMed, Scopus, and Google Scholar, initially identifying 1,276 articles. After removing duplicates and screening titles, abstracts, and full texts, 92 studies with valid data were included in the final analysis.
Results: Specific antiviral treatments for dengue are under development, with some drugs targeting viral replication currently in clinical trials. Live-attenuated tetravalent vaccines have shown promising safety and efficacy results. Additionally, novel vector control strategies, including Wolbachia-infected mosquitoes and genetically modified Aedes species, have demonstrated significant reductions in virus transmission.
Conclusion: Dengue remains a growing global threat, necessitating effective preventive and control measures. The findings of this review emphasize the importance of vaccine development, research on antiviral treatments, and vector control through innovative strategies. Integrating these approaches could reduce the disease burden and prevent its further spread.
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Article number: 06 |
| Keywords: dengue fever, transmission, clinical manifestation, diagnosis, vaccines |
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Full-Text [PDF 630 kb]
(39 Downloads)
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Type of Study: مقاله ترجمه |
Subject:
Special
Received: 2025/01/29 | Accepted: 2025/02/19 | Published: 2025/05/29
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