[Home ] [Archive]   [ فارسی ]  
:: Main :: About :: Current Issue :: Archive :: Search :: Submit :: Contact ::
:: Volume 5, Issue 17 (3-2018) ::
NPWJM 2018, 5(17): 23-27 Back to browse issues page
The effect of cryotherapy on inflammation and volume of post-hypoxic lesions in male rat
Abstract:   (720 Views)
Introduction: hypoxia result in harmful changes in brain structure and function. Reduction of inflammation, inhibition of apoptosis, repair of damaged axons and angiogenesis are factors that can Helps repair nerve tissue in damaged areas and reduce complications.Cryotherapy reduces cellular damage by decreasing edema and complications caused by reperfusion.
Methods: In this study, 16 male Wistar rats ,weighing 250 g, were used in two groups include  hypoxia and treatment. For anesthesia, chloral hydrate was used IP at a dose of 400 mg / kg.The left carotid artery was temporarily interrupted for one hour and the oxygen supply was disrupted. By restarting the bloodstream, the ice pack is applied locally to the rat's neck for half an hour. After 24 hours, the rats were sacrified and the samples were stained with cresyl violet. Then taken with Canon's digital camera.Cerebral edema, lesion volume  and number of cell death were calculated and analyzed by SPSS software.
Results : Dead cells are reduced in the treatment group and normal cells are more likely to be seen. The use of topical cryotherapy has reduced brain edema. The volume of lesion in the treatment group was significantly lower than the hypoxia group.
Conclusion: The results of this study have shown that the use of topical cryotherapy reduces brain damage by reducing reperfusion complications. Using the results obtained from this study, it can be concluded that the use of topical cryotherapy has the same effect as drug that decrease in the body temperature but  can produce a favorable effect without systemic effects in the body and its long-term use is harmful. In addition, it is easy to use and available and can be used as an initial treatment and at the same time as other treatments
Keywords: Hypoxia, Ischemia, Brain, Cryotherapy, Rat
Full-Text [PDF 485 kb]   (307 Downloads)    
Type of Study: Research | Subject: Special
Received: 2018/07/9 | Accepted: 2018/07/9 | Published: 2018/07/9
Add your comments about this article
Your username or Email:

CAPTCHA


XML   Persian Abstract   Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

The effect of cryotherapy on inflammation and volume of post-hypoxic lesions in male rat. NPWJM. 2018; 5 (17) :23-27
URL: http://npwjm.ajaums.ac.ir/article-1-481-en.html


Volume 5, Issue 17 (3-2018) Back to browse issues page
پرستار و پزشک در رزم Nurse and Physician Within War
Persian site map - English site map - Created in 0.06 seconds with 32 queries by YEKTAWEB 4140