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The Effect of Eight Weeks of High-Intensity Interval Training with Nigella sativa Supplementation on MDA، TOC and TAC Indices in Rats with Type 2 Diabetes
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Sussan Ramsari   , Bahram Abedi , Lida Moradi |
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Abstract: (182 Views) |
Introduction: Attention to physical activity approaches and the use of herbal supplements has emerged as a strategy for better diabetes management. Therefore, the aim of this study was to investigate the effect of eight weeks of high-intensity interval training (HIIT) combined with black seed (Nigella sativa) supplementation on oxidative stress markers in rats with type 2 diabetes.
Methods: This was a semi-experimental study. Forty rats, after one week of adaptation, were divided into five groups: healthy control, diabetic control, exercise, supplement, and exercise + supplement. Diabetes was induced by intraperitoneal injection of streptozotocin at a dose of 50 mg/kg of body weight. The high-intensity interval training consisted of running sessions for eight weeks. Black seed extract was administered orally by gavage at the end of each training session at an effective dose of 400 mg/kg/day.
Results: The results showed a reduction in serum levels of MDA and TOC due to high-intensity interval training and black seed supplementation compared to the diabetic control group. This effect in the HIIT + black seed group led to a decrease in TOC and MDA levels to the extent observed in the healthy control group. Furthermore, serum TAC levels increased in response to HIIT and black seed supplementation. HIIT alone was more effective than black seed supplementation alone in increasing serum TAC levels.
Conclusion: Overall, this study highlights the importance of using combined approaches involving exercise and antioxidant supplements in managing type 2 diabetes.
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Article number: 6 |
| Keywords: High-Intensity Interval Training, Black Seed, Malondialdehyde, Total Antioxidant Capacity, Total Oxidative Capacity |
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Full-Text [PDF 274 kb]
(117 Downloads)
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Type of Study: Research |
Subject:
Special
Received: 2025/05/7 | Accepted: 2025/08/3 | Published: 2025/10/10
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