fa بررسی همه گیرشناسی میزان اختلالات خواب و نشانگان بالینی در بیماران مبتلا به سلیاک استان خراسان رضوی تخصصي Special پژوهشي Research <span style="font-size:11pt"><span style="direction:rtl"><span style="unicode-bidi:embed"><span style="line-height:107%"><span calibri="" style="font-family:"><b><span lang="AR-SA" style="font-size:12.0pt"><span style="background:maroon"><span style="line-height:107%"><span b="" nazanin="" style="font-family:">مقدمه:</span></span></span></span></b><span lang="AR-SA" style="font-size:12.0pt"><span style="background:maroon"><span style="line-height:107%"><span b="" nazanin="" style="font-family:"> پژوهش حاضر با هدف بررسی همه گیرشناسی میزان اختلالات خواب و نشانگان بالینی در بیماران مبتلا به سلیاک استان خراسان رضوی انجام شد</span></span></span></span><span dir="LTR" style="font-size:12.0pt"><span style="background:maroon"><span style="line-height:107%">.</span></span></span> <span lang="AR-SA" style="font-size:12.0pt"><span style="background:maroon"><span style="line-height:107%"><span b="" nazanin="" style="font-family:">این</span></span></span></span> <span lang="AR-SA" style="font-size:12.0pt"><span style="background:maroon"><span style="line-height:107%"><span b="" nazanin="" style="font-family:">پژوهش</span></span></span></span> <span lang="AR-SA" style="font-size:12.0pt"><span style="background:maroon"><span style="line-height:107%"><span b="" nazanin="" style="font-family:">توصیفی،</span></span></span></span> <span lang="AR-SA" style="font-size:12.0pt"><span style="background:maroon"><span style="line-height:107%"><span b="" nazanin="" style="font-family:">از</span></span></span></span> <span lang="AR-SA" style="font-size:12.0pt"><span style="background:maroon"><span style="line-height:107%"><span b="" nazanin="" style="font-family:">نوع</span></span></span></span> <span lang="AR-SA" style="font-size:12.0pt"><span style="background:maroon"><span style="line-height:107%"><span b="" nazanin="" style="font-family:">علی</span></span></span></span><span dir="LTR" style="font-size:12.0pt"><span style="background:maroon"><span style="line-height:107%">- </span></span></span><span lang="AR-SA" style="font-size:12.0pt"><span style="background:maroon"><span style="line-height:107%"><span b="" nazanin="" style="font-family:">مقایسه</span></span></span></span><span dir="LTR" style="font-size:12.0pt"><span style="background:maroon"><span style="line-height:107%">‌</span></span></span><span lang="AR-SA" style="font-size:12.0pt"><span style="background:maroon"><span style="line-height:107%"><span b="" nazanin="" style="font-family:">ای می باشد.</span></span></span></span><span lang="AR-SA" style="font-size:12.0pt"><span style="line-height:107%"><span style="font-family:"B Nazanin""></span></span></span></span></span></span></span></span><br> <span style="font-size:11pt"><span style="direction:rtl"><span style="unicode-bidi:embed"><span style="line-height:107%"><span calibri="" style="font-family:"><b><span lang="AR-SA" style="font-size:12.0pt"><span style="line-height:107%"><span b="" nazanin="" style="font-family:">روش کار:</span></span></span></b><span lang="AR-SA" style="font-size:12.0pt"><span style="line-height:107%"><span b="" nazanin="" style="font-family:"> در این پژوهش تعداد 260 بیمار مبتلا به سلیاک بر اساس جدول مورگان از میان مراجعه کنندگان به بیمارستان امام رضا (ع) شهر مشهد، انتخاب شدند که توسط متخصص گوارش وبیوپسی روده تشخیص داده شده بودند. </span></span></span><span lang="FA" style="font-size:12.0pt"><span style="line-height:107%"><span b="" nazanin="" style="font-family:">۲۶۰</span></span></span> <span lang="AR-SA" style="font-size:12.0pt"><span style="line-height:107%"><span b="" nazanin="" style="font-family:">نفر از افراد سالم به روش نمونه گیری در دسترس انتخاب شدند و در یک مرحله به پرسشنامه های وضعیت خواب آلودگی ایپورث (</span></span></span><span dir="LTR" style="font-size:10.0pt"><span style="line-height:107%"><span new="" roman="" style="font-family:" times="">ESS</span></span></span><span lang="FA" style="font-size:12.0pt"><span style="line-height:107%"><span b="" nazanin="" style="font-family:">)</span></span></span><span lang="AR-SA" style="font-size:12.0pt"><span style="line-height:107%"><span b="" nazanin="" style="font-family:">، شاخص شدت بیخوابی (</span></span></span><span dir="LTR" style="font-size:10.0pt"><span style="line-height:107%"><span new="" roman="" style="font-family:" times="">ISI</span></span></span><span lang="FA" style="font-size:12.0pt"><span style="line-height:107%"><span b="" nazanin="" style="font-family:">)</span></span></span><span lang="AR-SA" style="font-size:12.0pt"><span style="line-height:107%"><span b="" nazanin="" style="font-family:">، ارزیابی سندرم پای بیقرار (</span></span></span><span dir="LTR" style="font-size:10.0pt"><span style="line-height:107%"><span new="" roman="" style="font-family:" times="">RLS</span></span></span><span lang="FA" style="font-size:12.0pt"><span style="line-height:107%"><span b="" nazanin="" style="font-family:">)</span></span></span><span lang="AR-SA" style="font-size:12.0pt"><span style="line-height:107%"><span b="" nazanin="" style="font-family:">، ارزیابی ابتلا به آپنه انسدادی خواب (</span></span></span><span dir="LTR" style="font-size:10.0pt"><span style="line-height:107%"><span new="" roman="" style="font-family:" times="">Berlin</span></span></span><span lang="FA" style="font-size:12.0pt"><span style="line-height:107%"><span b="" nazanin="" style="font-family:">)</span></span></span><span lang="AR-SA" style="font-size:12.0pt"><span style="line-height:107%"><span b="" nazanin="" style="font-family:">، شاخص کیفیت خواب (</span></span></span><span dir="LTR" style="font-size:10.0pt"><span style="line-height:107%"><span new="" roman="" style="font-family:" times="">PSQI</span></span></span><span lang="FA" style="font-size:12.0pt"><span style="line-height:107%"><span b="" nazanin="" style="font-family:">)</span></span></span> <span lang="AR-SA" style="font-size:12.0pt"><span style="line-height:107%"><span b="" nazanin="" style="font-family:">و پرسشنامه افسردگی، اضطراب و تنیدگی</span></span></span> <span lang="AR-SA" style="font-size:12.0pt"><span style="line-height:107%"><span b="" nazanin="" style="font-family:">(</span></span></span><span dir="LTR" style="font-size:10.0pt"><span style="line-height:107%"><span new="" roman="" style="font-family:" times="">DASS</span></span></span><span lang="FA" style="font-size:12.0pt"><span style="line-height:107%"><span b="" nazanin="" style="font-family:">)</span></span></span> <span lang="AR-SA" style="font-size:12.0pt"><span style="line-height:107%"><span b="" nazanin="" style="font-family:">پاسخ دادند. برای تحلیل داده ها از روش تحلیل واریانس توسط نرمافزار</span></span></span> <span dir="LTR" style="font-size:10.0pt"><span style="line-height:107%"><span new="" roman="" style="font-family:" times="">spss22 </span></span></span><span lang="AR-SA" style="font-size:12.0pt"><span style="line-height:107%"><span b="" nazanin="" style="font-family:">استفاده شد</span></span></span><span dir="LTR" style="font-size:12.0pt"><span style="line-height:107%">. </span></span><span lang="AR-SA" style="font-size:12.0pt"><span style="line-height:107%"><span style="font-family:"B Nazanin""></span></span></span></span></span></span></span></span><br> <span style="font-size:11pt"><span style="direction:rtl"><span style="unicode-bidi:embed"><span style="line-height:107%"><span calibri="" style="font-family:"><b><span lang="AR-SA" style="font-size:12.0pt"><span style="line-height:107%"><span b="" nazanin="" style="font-family:">نتایج:</span></span></span></b><span lang="AR-SA" style="font-size:12.0pt"><span style="line-height:107%"><span b="" nazanin="" style="font-family:"> بین بیماران مبتلا به سلیاک و افراد سالم در وضعیت خواب آلودگی، شدت بیخوابی، سندرم پای بیقرار و آپنه انسدادی خواب و نشانگان بالینی تفاوت معناداری وجود دارد (001/0</span></span></span><span dir="LTR" style="font-size:10.0pt"><span style="line-height:107%"><span new="" roman="" style="font-family:" times="">p</span></span></span><span dir="LTR" style="font-size:12.0pt"><span style="line-height:107%"><</span></span><span lang="AR-SA" style="font-size:12.0pt"><span style="line-height:107%"><span b="" nazanin="" style="font-family:">). شاخص اندازه اثر نشان داد 12 درصد اختلالات خواب و نشانگان بالینی مرتبط با اثر بیماری سلیاک است و گروه بیماران مبتلا به سلیاک میانگین وضعیت</span></span></span> &nbsp;&nbsp;<span dir="LTR" style="font-size:10.0pt"><span style="line-height:107%"><span new="" roman="" style="font-family:" times="">Ttg1 </span></span></span><span lang="AR-SA" style="font-size:12.0pt"><span style="line-height:107%"><span b="" nazanin="" style="font-family:">بالاتر از</span></span></span> <span dir="LTR" style="font-size:10.0pt"><span style="line-height:107%"><span new="" roman="" style="font-family:" times="">Ttg2 </span></span></span><span lang="AR-SA" style="font-size:12.0pt"><span style="line-height:107%"><span b="" nazanin="" style="font-family:">دارند.</span></span></span></span></span></span></span></span><br> <b><span dir="RTL" lang="AR-SA" style="font-size:12.0pt"><span style="line-height:107%"><span b="" nazanin="" style="font-family:">بحث و نتیجه گیری:</span></span></span></b><span dir="RTL" lang="AR-SA" style="font-size:12.0pt"><span style="line-height:107%"><span b="" nazanin="" style="font-family:"> <span style="background:red">مشکلات خواب باعث ایجاد یکسری عوامل التهابی در بدن می شود که با توجه به این پژوهش می توان نتجه گرفت که رژیم غذایی بدون گلوتن تاثیری در مهار این عوامل و در نتیجه کاهش اختلالات خواب در بیماران مبتلا به سلیاک می تواند داشته باشد. </span></span></span></span> <span style="font-size:11pt"><span style="line-height:107%"><span calibri="" style="font-family:"><b><span style="font-size:12.0pt"><span style="background:teal"><span style="line-height:107%"><span new="" roman="" style="font-family:" times="">Introduction:</span></span></span></span></b> <span style="font-size:12.0pt"><span style="background:teal"><span style="line-height:107%"><span new="" roman="" style="font-family:" times="">The present study was conducted with the aim of investigating the epidemiology of sleep disorders and clinical symptoms in patients with celiac disease in Razavi Khorasan province. This descriptive research is causal-comparative.</span></span></span></span></span></span></span><br> <span style="font-size:11pt"><span style="line-height:107%"><span calibri="" style="font-family:"><b><span style="font-size:12.0pt"><span style="background:teal"><span style="line-height:107%"><span new="" roman="" style="font-family:" times="">Material and Methods:</span></span></span></span></b> <span style="font-size:12.0pt"><span style="background:teal"><span style="line-height:107%"><span new="" roman="" style="font-family:" times="">In this study, 260 patients with celiac disease were selected according to Morgan&#39;s table among those who referred to Imam Reza Hospital in Mashhad, who were diagnosed by a gastroenterologist and underwent intestinal biopsy. 260 healthy people were selected by available sampling method and in one step they were asked the Epworth Sleepiness Status (ESS), Insomnia Severity Index (ISI), Restless Leg Syndrome (RLS) and Obstructive Sleep Apnea (OSA) questionnaires. Berlin), Sleep Quality Index (PSQI) and Depression, Anxiety and Stress Questionnaire (DASS). Analysis of variance was used by spss22 software to analyze the data.</span></span></span></span></span></span></span><br> <span style="font-size:11pt"><span style="line-height:107%"><span calibri="" style="font-family:"><b><span style="font-size:12.0pt"><span style="background:teal"><span style="line-height:107%"><span new="" roman="" style="font-family:" times="">Results:</span></span></span></span></b> <span style="font-size:12.0pt"><span style="background:teal"><span style="line-height:107%"><span new="" roman="" style="font-family:" times="">There is a significant difference between celiac disease patients and healthy people in sleepiness, insomnia severity, restless leg syndrome, obstructive sleep apnea and clinical symptoms (p<0.001). The effect size index showed that 12% of sleep disorders and clinical symptoms are related to the effect of celiac disease, and the group of patients with celiac disease has a higher average Ttg1 status than Ttg2.</span></span></span></span></span></span></span><br> <span style="font-size:11pt"><span style="line-height:107%"><span calibri="" style="font-family:"><b><span style="font-size:12.0pt"><span style="background:teal"><span style="line-height:107%"><span new="" roman="" style="font-family:" times="">conclusion:</span></span></span></span></b> <span style="font-size:12.0pt"><span style="background:teal"><span style="line-height:107%"><span new="" roman="" style="font-family:" times="">Sleep problems cause a series of inflammatory factors in the body, and according to this research, it can be concluded that gluten-free diet has an effect on controlling these factors and thus reducing sleep disorders in celiac patients.</span></span></span></span></span></span></span> همه گیرشناسی, سلیّاک, اختلالات خواب, نشانگان بالینی Epidemiology, Celiac Disease, Sleep Disorders, Clinical Syndrome 74 83 http://npwjm.ajaums.ac.ir/browse.php?a_code=A-10-3145-1&slc_lang=fa&sid=1 behnaz khodaverdi بهناز خداوردی behnakhoda@gmail.com 10031947532846005409 10031947532846005409 No Department of Psychology, Torbat-e Jam Branch, Islamic Azad University, Torbat-e Jam, Iran گروه روانشناسی، واحد تربت جام، دانشگاه آزاد اسلامی، تربت جام، ایران azita keshavarz آزیتا کشاورز Azita.kheshavarz@yahoo.com 10031947532846005410 10031947532846005410 Yes Department of Psychology, Torbat-e Jam Branch, Islamic Azad University, Torbat-e Jam, Iran گروه روانشناسی، واحد تربت جام، دانشگاه آزاد اسلامی، تربت جام، ایران azita ganji آزیتا گنجی Ganji.azita@gmail.com 10031947532846005411 10031947532846005411 No Associate Professor of Gastroenterology and Hepatology, Faculty of medicine, Mashhad University of Medical Sciences, Mashhad, Iran. دانشیار و فوق تخصص گوارش و کبد بالغین، گروه داخلی، دانشکده پزشکی، دانشگاه علوم پزشکی مشهد، مشهد، ایران