fa بررسی سطوح سرمی و بزاقی کراتینین در بیماری التهابی روده تخصصي Special پژوهشي Research <span style="font-size:11pt"><span style="line-height:115%"><span style="direction:rtl"><span style="unicode-bidi:embed"><span sans-serif="" style="font-family:Calibri,"><b><span lang="FA" style="font-size:12.0pt"><span style="line-height:115%"><span b="" nazanin="" style="font-family:"><span style="color:black">مقدمه:</span></span></span></span></b><span lang="FA" style="font-size:12.0pt"><span style="line-height:115%"><span b="" nazanin="" style="font-family:"><span style="color:black"> بیماری التهابی روده (</span></span></span></span><span dir="LTR" style="font-size:12.0pt"><span style="line-height:115%"><span new="" roman="" style="font-family:" times=""><span style="color:black">IBD</span></span></span></span><span lang="FA" style="font-size:12.0pt"><span style="line-height:115%"><span b="" nazanin="" style="font-family:"><span style="color:black">) یک بیماری سیستمیک و مزمن سیستم گوارش است که سالانه میلیون ها نفر را تحت تاثیر قرار می دهد. با توجه به امکان درگیری کلیوی به عنوان تظاهر خارج روده ای بیماری تصمیم به بررسی مقایسه سطح سرمی و بزاقی کراتینین در افراد مبتلا و گروه سالم گرفتیم.</span></span></span></span><span dir="LTR" style="font-size:12.0pt"><span style="line-height:115%"><span new="" roman="" style="font-family:" times=""><span style="color:black"></span></span></span></span></span></span></span></span></span><br> <span style="font-size:11pt"><span style="line-height:115%"><span style="direction:rtl"><span style="unicode-bidi:embed"><span sans-serif="" style="font-family:Calibri,"><b><span lang="FA" style="font-size:12.0pt"><span style="line-height:115%"><span b="" nazanin="" style="font-family:"><span style="color:black">روش کار:</span></span></span></span></b><span lang="FA" style="font-size:12.0pt"><span style="line-height:115%"><span b="" nazanin="" style="font-family:"><span style="color:black">&nbsp;در مطلعه مقطعی، 30 فرد مبتلا به </span></span></span></span><span dir="LTR" style="font-size:12.0pt"><span style="line-height:115%"><span new="" roman="" style="font-family:" times=""><span style="color:black">IBD</span></span></span></span><span lang="FA" style="font-size:12.0pt"><span style="line-height:115%"><span b="" nazanin="" style="font-family:"><span style="color:black"> و 30 فرد سالم وارد مطالعه شدند. سرم و بزاق غیر تحریکی در صبح گرفته شد و میزان کراتینین به روش فتومتریک اندازه گیری شد. داده ها به وسیله&nbsp;&nbsp; </span></span></span></span><span dir="LTR" style="font-size:12.0pt"><span style="line-height:115%"><span new="" roman="" style="font-family:" times=""><span style="color:black">t-test</span></span></span></span><span lang="FA" style="font-size:12.0pt"><span style="line-height:115%"><span b="" nazanin="" style="font-family:"><span style="color:black">&nbsp; با استفاده از نرم افزار </span></span></span></span><span dir="LTR" style="font-size:12.0pt"><span style="line-height:115%"><span new="" roman="" style="font-family:" times=""><span style="color:black">SPSS</span></span></span></span><span lang="FA" style="font-size:12.0pt"><span style="line-height:115%"><span b="" nazanin="" style="font-family:"><span style="color:black"> نسخه 22 مورد تجزیه و تحلیل قرار گرفت. </span></span></span></span><span dir="LTR" style="font-size:12.0pt"><span style="line-height:115%"><span new="" roman="" style="font-family:" times=""><span style="color:black">P<0.05</span></span></span></span><span lang="FA" style="font-size:12.0pt"><span style="line-height:115%"><span b="" nazanin="" style="font-family:"><span style="color:black"> معنی دار در نظر گرفته شد.</span></span></span></span><span dir="LTR" style="font-size:12.0pt"><span style="line-height:115%"><span new="" roman="" style="font-family:" times=""><span style="color:black"></span></span></span></span></span></span></span></span></span><br> <span style="font-size:11pt"><span style="line-height:115%"><span style="direction:rtl"><span style="unicode-bidi:embed"><span sans-serif="" style="font-family:Calibri,"><b><span lang="FA" style="font-size:12.0pt"><span style="line-height:115%"><span b="" nazanin="" style="font-family:"><span style="color:black">یافته ها:</span></span></span></span></b><span lang="FA" style="font-size:12.0pt"><span style="line-height:115%"><span b="" nazanin="" style="font-family:"><span style="color:black"> در این مطالعه 30 بیمار مبتلا به </span></span></span></span><span dir="LTR" style="font-size:12.0pt"><span style="line-height:115%"><span new="" roman="" style="font-family:" times=""><span style="color:black">IBD</span></span></span></span><span lang="FA" style="font-size:12.0pt"><span style="line-height:115%"><span b="" nazanin="" style="font-family:"><span style="color:black"> با میانگین سنی 2.3 </span></span></span></span><span lang="FA" style="font-size:12.0pt"><span style="line-height:115%"><span cambria="" style="font-family:"><span style="color:black">&plusmn;</span></span></span></span><span lang="FA" style="font-size:12.0pt"><span style="line-height:115%"><span b="" nazanin="" style="font-family:"><span style="color:black"> 37.7 سال و 30 فرد سالم با میانگین سنی 2.2 </span></span></span></span><span lang="FA" style="font-size:12.0pt"><span style="line-height:115%"><span cambria="" style="font-family:"><span style="color:black">&plusmn;</span></span></span></span><span lang="FA" style="font-size:12.0pt"><span style="line-height:115%"><span b="" nazanin="" style="font-family:"><span style="color:black"> 32.5 سال&nbsp; مشارکت کردند. شاخص توده بدنی گروه </span></span></span></span><span dir="LTR" style="font-size:12.0pt"><span style="line-height:115%"><span new="" roman="" style="font-family:" times=""><span style="color:black">IBD</span></span></span></span><span lang="FA" style="font-size:12.0pt"><span style="line-height:115%"><span b="" nazanin="" style="font-family:"><span style="color:black"> 0.68 </span></span></span></span><span lang="FA" style="font-size:12.0pt"><span style="line-height:115%"><span cambria="" style="font-family:"><span style="color:black">&plusmn;</span></span></span></span><span lang="FA" style="font-size:12.0pt"><span style="line-height:115%"><span b="" nazanin="" style="font-family:"><span style="color:black"> 25.5 و گروه سالم 34/1 </span></span></span></span><span lang="FA" style="font-size:12.0pt"><span style="line-height:115%"><span cambria="" style="font-family:"><span style="color:black">&plusmn;</span></span></span></span><span lang="FA" style="font-size:12.0pt"><span style="line-height:115%"><span b="" nazanin="" style="font-family:"><span style="color:black"> 2/26 بود که تفاوت معنی داری در این پارامترها وجود نداشت(</span></span></span></span><span dir="LTR" style="font-size:12.0pt"><span style="line-height:115%"><span new="" roman="" style="font-family:" times=""><span style="color:black">p>0.05</span></span></span></span><span lang="FA" style="font-size:12.0pt"><span style="line-height:115%"><span b="" nazanin="" style="font-family:"><span style="color:black">). همچنین نتایج نشان داد که میانگین سطح سرمی و بزاقی کراتینین تفاوت معنی داری در دو گروه نداشت.</span></span></span></span><span dir="LTR" style="font-size:12.0pt"><span style="line-height:115%"><span new="" roman="" style="font-family:" times=""><span style="color:black"></span></span></span></span></span></span></span></span></span><br> <span style="font-size:11pt"><span style="line-height:115%"><span style="direction:rtl"><span style="unicode-bidi:embed"><span sans-serif="" style="font-family:Calibri,"><b><span lang="FA" style="font-size:12.0pt"><span style="line-height:115%"><span b="" nazanin="" style="font-family:"><span style="color:black">نتیجه گیری:</span></span></span></span></b><span lang="FA" style="font-size:12.0pt"><span style="line-height:115%"><span b="" nazanin="" style="font-family:"><span style="color:black"> به نظر می‌رسد سطح کراتینین در بیماران مبتلا به </span></span></span></span><span dir="LTR" style="font-size:12.0pt"><span style="line-height:115%"><span new="" roman="" style="font-family:" times=""><span style="color:black">IBD</span></span></span></span><span style="font-size:12.0pt"><span style="line-height:115%"><span b="" nazanin="" style="font-family:"><span style="color:black"> و افراد سالم تغییری پیدا نمی کند و در سال های اولیه بیماری درگیری کلیوی و کاهش عملکرد آن رخ نمی دهد.</span></span></span></span></span></span></span></span></span> <span style="font-size:11pt"><span style="line-height:115%"><span sans-serif="" style="font-family:Calibri,"><b><span style="font-size:12.0pt"><span style="line-height:115%"><span new="" roman="" style="font-family:" times=""><span style="color:black">Introduction:</span></span></span></span></b><span style="font-size:12.0pt"><span style="line-height:115%"><span new="" roman="" style="font-family:" times=""><span style="color:black"> Inflammatory bowel disease (IBD) is a systemic and chronic disease of the digestive system that affects millions of people every year. Considering the possibility of renal involvement as an extra-intestinal manifestation of the disease, we decided to compare creatinine levels in serum and saliva of the affected and healthy groups</span></span></span></span><span dir="RTL" lang="FA" style="font-size:12.0pt"><span style="line-height:115%"><span b="" nazanin="" style="font-family:"><span style="color:black">.</span></span></span></span><span style="font-size:12.0pt"><span style="line-height:115%"><span new="" roman="" style="font-family:" times=""><span style="color:black"></span></span></span></span></span></span></span><br> <span style="font-size:11pt"><span style="line-height:115%"><span sans-serif="" style="font-family:Calibri,"><b><span style="font-size:12.0pt"><span style="line-height:115%"><span new="" roman="" style="font-family:" times=""><span style="color:black">Method:</span></span></span></span></b><span style="font-size:12.0pt"><span style="line-height:115%"><span new="" roman="" style="font-family:" times=""><span style="color:black"> In a cross-sectional study, 30 subjects with IBD and 30 healthy subjects were included. Non-stimulated serum and saliva were collected in the morning and creatinine was measured photometrically. Data were analyzed by t-test using SPSS version 22 software. P<0.05 was considered significant</span></span></span></span><span dir="RTL" lang="FA" style="font-size:12.0pt"><span style="line-height:115%"><span b="" nazanin="" style="font-family:"><span style="color:black">.</span></span></span></span> <span style="font-size:12.0pt"><span style="line-height:115%"><span new="" roman="" style="font-family:" times=""><span style="color:black"></span></span></span></span></span></span></span><br> <span style="font-size:11pt"><span style="line-height:115%"><span sans-serif="" style="font-family:Calibri,"><span style="font-size:12.0pt"><span style="line-height:115%"><span new="" roman="" style="font-family:" times=""><span style="color:black"><b>Finding:</b> 30 patients with IBD with a mean age of 37.7 &plusmn; 2.3 years and 30 healthy individuals with a mean age of 32.5 &plusmn; 2.2 years participated in this study. The body mass index of the IBD group was 25.5 &plusmn; 0.68 and that of the healthy group was 26.2 &plusmn; 1.34, and there was no significant difference in these parameters (p>0.05). The results also showed that the mean serum and salivary creatinine levels were not significantly different in the two groups.</span></span></span></span></span></span></span><br> <span style="font-size:11pt"><span style="line-height:115%"><span sans-serif="" style="font-family:Calibri,"><b><span style="font-size:12.0pt"><span style="line-height:115%"><span new="" roman="" style="font-family:" times=""><span style="color:black">Conclusion:</span></span></span></span></b><span style="font-size:12.0pt"><span style="line-height:115%"><span new="" roman="" style="font-family:" times=""><span style="color:black"> It seems that creatinine levels do not change in patients with IBD and healthy people, and there is no renal involvement and no decline in renal function in the early years of the disease.</span></span></span></span></span></span></span> بیماری التهابی روده؛ کراتینین؛ بزاق؛ سرم inflammatory bowel disease, creatinine, saliva, serum 36 41 http://npwjm.ajaums.ac.ir/browse.php?a_code=A-10-4525-1&slc_lang=fa&sid=1 Peyman Aslani پیمان اصلانی PeymanAslani@yahoo.com 10031947532846006644 10031947532846006644 No Aja University of Medical Sciences دانشگاه علوم پزشکی آجا Iraj Mirzaii-Dizgah ایرج میرزایی دیزگاه emirzaii@alumnus.tums.ac.ir 10031947532846006645 10031947532846006645 No Aja University of Medical Sciences دانشگاه علوم پزشکی آجا Elahe Alavi Afrakoti الهه علوی افراکتی elahealavi1@gmail.com 10031947532846006646 10031947532846006646 No Aja University of Medical Sciences دانشگاه علوم پزشکی آجا Mohammad Arbaghaei محمد اربقائی arbaghaei.mohammad@gmail.com 10031947532846006647 10031947532846006647 Yes Aja University of Medical Sciences دانشگاه علوم پزشکی آجا