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Evaluation of the Value of Procalcitonin Level in The Diagnosis of Neonatal Sepsis
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Farnam Iran-Nezhadi-Bozorgi   , Koroush Kosari , Alireza Aminian , Saeed Soliman meigoni , Amir Parsa Kosari |
| Department of Pediatrics, Faculty of Medicine, Aja University of Medical Sciences, Tehran, Iran |
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Abstract: (402 Views) |
Introduction: Regard to the importance of sepsis in newborns, the lack of a specific biomarker for this disease, and the increasing role of calcitonin in recent years, we conducted this study to evaluate the diagnostic value of procalcitonin in newborns with sepsis.
Methods: A pediatric infectious diseases specialist confirmed the diagnosis and included newborns with neonatal sepsis in this study. We collected two cc of peripheral blood from the newborns to measure procalcitonin along with other routine tests. We analyzed the quantitative and qualitative data using SPSS software version 22 by the Chi-square, Fisher, and U Mann-Whitney tests.
Results: The study included 51 newborns. Of these, 29 (56.9%) were female and 22 (43.1%) were male. The mean gestational age was 33.2 ± 3.14 weeks, and the mean birth weight of the newborns was 2028 ± 894 grams. Of the 51 infants, only 4 infants (7.8%) had positive blood cultures, 36 infants (76.5%) had positive CRP tests, and 16 infants (31.4%) had positive procalcitonin tests. The mean procalcitonin level in infants with positive blood cultures was 0.56 ± 0.71 ng/ml, and in infants with negative cultures, it was 0.268 ± 0.37 which was a statistically significant difference (p = 0.029).
Discussion: We concluded that the procalcitonin test serves as a valuable marker for diagnosing neonatal sepsis. However, neonatal sepsis is an acute life-threatening condition and diagnostic tests for this disease should have higher sensitivity, and procalcitonin cannot serve as the sole diagnostic marker.
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Article number: 6 |
| Keywords: procalcitonin, neonatal, sepsis |
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Full-Text [PDF 268 kb]
(126 Downloads)
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Type of Study: Research |
Subject:
Special
Received: 2025/01/3 | Accepted: 2025/01/3 | Published: 2025/01/3
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